Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3

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Regulation of Early Cartilage Destruction in Inflammatory Arthritis by Death Receptor 3

OBJECTIVE To investigate the role of death receptor 3 (DR-3) and its ligand tumor necrosis factor-like molecule 1A (TL1A) in the early stages of inflammatory arthritis. METHODS Antigen-induced arthritis (AIA) was generated in C57BL/6 mice deficient in the DR-3 gene (DR3(-/-) ) and their DR3(+/+) (wild-type) littermates by priming and intraarticular injection of methylated bovine serum albumin...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatology

سال: 2014

ISSN: 2326-5191

DOI: 10.1002/art.38770